From: A news that made me sad……
I just came back from Teluk Intan Hospital. En.Jaafar was admitted there from the second day of Raya. He look wasted, cachetic and his eyes were tainted yellow of we call jaundice. He had a tube which was inserted through the nose to drain the contents of his stomach as he was vomiting persistently. He had fluids running into his veins. I was impressed to see the MO still there talking to him at 3pm on a weekend.
He was extremely happy and comforted to see me. I was happy he recognised me - there he was losing weight and I am gaining. I was dissappointed he did not consult me earlier. He had pancreatic cancer which had infiltrated the duodenum causing obstructon and there is also evidence of liver involvement. He is presently obstructed at the least the duodenum and bile duct. Usually, this would also mean obstruction to the pancreatic duct. I will see how I can help him despite being advanced in nature.
For those who are unsure what I am talking about, let me explain a little.

Definition
Uncontrolled growth of abnormal cells that tends to form a mass and destroys the normal cells and invade neighouring structures or move(spread) to other areas of the body.
Signs and Symptoms
Often then not, it is absent - no symptoms or subtle. Thus I termed it the silent killer. By the time there is symptoms, it is usually late. The common symptoms are abdominal pain, nausea, loss of appetite, unexplained weight loss, and jaundice. These are symptoms that could also be a presentation of other cancers.
Test
There are no spesific laboratory tests available for the early detection or diagnosis of pancreatic cancer.
The common laboratory tests that can be done but non spesific are:
1. CA 19-9 (Cancer Antigen 19-9): a tumor marker for pancreatic cancer; it may be used to monitor for cancer recurrence but is not useful for detection or diagnosis.
2. Other metabolic test - Liver function, kidney function, glucose levels, and the rarer test for pancreatic function - fecal fat, stool trypsin, trypsinogen, amylase, and lipase
Radiological investigations like
1. CT (computed tomography) scan: useful for detecting pancreas masses and checking for metastasized cancer. Can do biopsy together for diagnostic purpose if a mass is present
2. MRI (magnetic resonance imaging)
3. Endoscopic Ultrasound (EUS) — for diagnosis, biopsy and looking for invasion or spread
4. Endoscopic retrograde cholangiopancreatography (ERCP)
5. PET scan (positron emission tomography scan)
Surgical methods are laparoscopic staging - looking for invasion and spread and assess for possibility of surgery.
Prevention
The main risk factor for pancreatic cancer is preventable: smoking. About 30% of pancreatic cancers are thought to be a direct result of cigarette smoking. Other risks include:
* Age (most often seen in those older than 60)
* Gender (Men are 30% more likely to develop pancreatic cancer)
* Chronic pancreatitis
* Diet (a diet high in meats and fats appears to increase risk)
* Diabetes mellitus
* Exposure to some industrial chemicals, such as certain pesticides and petroleum products
* Family History (an inherited tendency may be a factor in 5% to 10% of cases)
But there are many who do get pancreatic cancer have none of these risk factors.
Treatment & Outcome
Once diagnosed and staged (that is to assess how far the cancer has evolved), then there are 2 options - resectable or non-resectable.
Resectable would mean that the surgeon will be able to remove the growth. Unfortunately resection (removal) is possible less than 15% of the time. How much surgery is done depends on where the tumor is, its size, how far it has spread, and the patient’s health.
Radiation and chemotherapy also may be used and are often necessary as tiny, undetectable amounts of the tumor have often spread by the time surgery is done. Unfortunately, pancreatic cancer does not respond well to current treatments.
Non-resectable means the only option is for palliative(comfort-oriented) care. Surgery — to relieve an obstructed system by way of bypass or endoscopic stenting, Chemotherapy and radiation for pain relief.
For patients with advanced cancers, the overall survival rate of all stages is <1% at 5 years with most patients dying within 1 year
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